Dopamine

Dopamine is a catecholamine neurotransmitter which is a chemical released by union kiosks to send call fors to other never cells, and plays an important role two central and peripheral nervous system. It helps control the brain to take ordure and emotional responses. Dopamine is made within dopamine neurons in the upper brainstem in the substantia Nigra. The site of movement of dopamine transmission affects atomic number 18 shown in the fig. 1. This is the dopamine driveway: L-Tyrosine ? L-DOPA ? Dopamine ? Norepinephrine ? epinephrine Levodopa is converted to dopamine by the work on of the enzyme dopa-decarboxylase in the brain Dopamine is stored in and remains in axon terminals and released when the neuron is depolarised Dopamine interacts with specific membrane receptors to build up its effects, uses five known types of dopamine receptors, these receptors are labeled D1, D2, D3, D4, and D5 and they are G protein-coupled receptors. Receptor effects terminated b y reuptake into the presynaptic neuron by a dopamine conveyor or by metabolic inactivation by monoamine oxidase B (MAO-B) or catechol-0-methyltransferase (COMT) Upon price reduction, dopamine is transported from the cell into synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2).

Dopamine is stored in and remains in these vesicles until an process potential occurs and forces them to merge with the cell membrane via a bound known as exocytosis, thereby dumping dopamine into synapses. at once in the synapse, dopamine binds to and activates postsynaptic dopamine receptors, resulting in the signal of the presynaptic cell being propagated to! the postsynaptic neuron. Dopamine also binds to presynaptic dopamine receptors, which kindle both excite the presynaptic cell or inhibit it depending on their galvanizing potential. Presynaptic receptors with an inhibitory potential are called autoreceptors and inhibit neurotransmitter synthesis and release. They swear out to keep dopamine levels normalized in certain...If you wish to get a full essay, order it on our website: OrderCustomPaper.com

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